反应详情

To a solution of cyclopropylcarbinol (360 mg, 5 mmol) and sodium hydride (110 m, 5 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (490 mg, 2.5 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 3 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to yield 400 m (69%) of the title compound.

1. extractionthe mixture was extracted with ether
2. dry with materialThe ether phase was dried
3. customevaporated