反应详情

1-Cyclohexyl-4-oxo-4,5-dihydroimidazo[1,5-a]quinoxaline-7-carboxyic acid as synthesized in Example 58, 300 mg, N,N-dimethylacetamide 5 mL and 1,1′-carbonyldiimidazole 266 mg were mixed and stirred for 30 minutes at room temperature. To the reaction liquid 143 mg of N-hydroxyacetamidine was added, followed by 12 hours' stirring at 110° C. After returning it to the room temperature, water was added thereto and the precipitated matter was recovered by filtration. Drying the precipitate by heating under reduced pressure, 210 mg of the title compound was obtained.

1. additionwere mixed
2. additionwas added
3. waitfollowed by 12 hours
4. stirring' stirring at 110° C
5. additionwas added
6. filtrationthe precipitated matter was recovered by filtration
7. customDrying the precipitate
8. temperatureby heating under reduced pressure