Hydrochloric Acid → HCID 10656224, compound

HRID 727418Notes

Reaction equation

HRID 727418 reaction equation
[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:12]2[C:15]3[C:4]=1[CH2:5][CH:6]([NH:16]C(=O)C)[CH2:7][C:8]=3[CH:9]=[CH:10][CH:11]=2.Cl.[OH-].[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:12]2[C:15]3[C:4]=1[CH2:5][CH:6]([NH2:16])[CH2:7][C:8]=3[CH:9]=[CH:10][CH:11]=2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 10355010HCID 10355010, compound

Product 1

HCID 10656224HCID 10656224, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

N-(4-Methoxy-2,3-dihydro-1H-phenalen-2-yl)acetamide (5.95mmol; 1.52g) is dissolved in 20 cm3 of ethanol to which are added 54 cm3 of 10% HCl. The mixture is maintained at 90° C. for 20 h. After cooling, 10% NaOH solution is added until the pH is basic and the amine is extracted with CH2Cl2. The organic phase is dried over MgSO4 and evaporated under reduced pressure. The title amine is thus isolated without further purification.

Workup

  1. temperatureAfter cooling
  2. extractionthe amine is extracted with CH2Cl2
  3. dry with materialThe organic phase is dried over MgSO4
  4. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-10dd12dca2fd4ad9bef0a42069798642
Source dataset
uspto-grants-1998_01
Patent number
US05712312

Reaction notes

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