Hydrochloric Acid → 4-[1-(1-Imidazolyl)-butyl]-benzoic acid, hydrochloride

HRID 727843Notes

Reaction equation

HRID 727843 reaction equation
[N:1]1([CH:6]([C:10]2[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=2)[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1.[ClH:19]>C(O)C>[ClH:19].[N:1]1([CH:6]([C:10]2[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=2)[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 145143684-[1-(1-Imidazolyl)-butyl]-benzoic acid

Product 1

HCID 145143694-[1-(1-Imidazolyl)-butyl]-benzoic acid, hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.0 g of 4-[1-(1-imidazolyl)-butyl]-benzoic acid is dissolved in 20 ml of ethanol and mixed with 10 ml of concentrated hydrochloric acid. The reaction mixture is precipitated into 100 ml of water and the precipitate is suctioned off. After recrystallization from ethanol, 0.95 g of 4-[1-(1-imidazolyl)-butyl]-benzoic acid, hydrochloride with a melting point of 38° C. is obtained.

Workup

  1. customThe reaction mixture is precipitated into 100 ml of water
  2. customAfter recrystallization from ethanol, 0.95 g of 4-[1-(1-imidazolyl)-butyl]-benzoic acid, hydrochloride with a melting point of 38° C.
  3. customis obtained

Sources & evidence

ORD record
ord-fc283fd46dc345c19663bdc84467f22e
Source dataset
uspto-grants-1991_09
Patent number
US05045558

Reaction notes

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