Tetrahydrofuran → 4-[1-(1-Imidazolyl)-butyl]-benzophenone

HRID 727851Notes

Reaction equation

HRID 727851 reaction equation
[N:1]1([CH:6]([C:10]2[CH:17]=[CH:16][C:13]([C:14]#N)=[CH:12][CH:11]=2)[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1.[C:18]1([Mg]Br)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[O:26]1CCCC1>>[N:1]1([CH:6]([C:10]2[CH:17]=[CH:16][C:13]([C:14]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:26])=[CH:12][CH:11]=2)[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 145143624-[1-(1-Imidazolyl)-butyl]-benzonitrileHCID 178418255HCID 178418255, compound

Product 1

HCID 145143654-[1-(1-Imidazolyl)-butyl]-benzophenone

Procedure

The 4-[1-(1-imidazolyl)-butyl]-benzonitrile is reacted with phenylmagnesium bromide under standard conditions analogously to example 11 in tetrahydrofuran. 0.83 g of 4-[1-(1-imidazolyl)-butyl]-benzophenone with a boiling point of 175° C./0.03 mbar is obtained.

Sources & evidence

ORD record
ord-a59209496495444088583fc45593208a
Source dataset
uspto-grants-1991_09
Patent number
US05045558

Reaction notes

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