Hydrochloric Acid → 4-[1-(1-Imidazolyl)-butyl]-benzoic acid methyl ester

HRID 727853Notes

Reaction equation

HRID 727853 reaction equation
Cl.[N:2]1([CH:7]([C:11]2[CH:19]=[CH:18][C:14]([C:15]([OH:17])=[O:16])=[CH:13][CH:12]=2)[CH2:8][CH2:9][CH3:10])[CH:6]=[CH:5][N:4]=[CH:3]1.Cl.[CH3:21]O>>[CH3:21][O:16][C:15](=[O:17])[C:14]1[CH:18]=[CH:19][C:11]([CH:7]([N:2]2[CH:6]=[CH:5][N:4]=[CH:3]2)[CH2:8][CH2:9][CH3:10])=[CH:12][CH:13]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 145143694-[1-(1-Imidazolyl)-butyl]-benzoic acid, hydrochloride

Product 1

HCID 145143744-[1-(1-Imidazolyl)-butyl]-benzoic acid methyl ester

Procedure

1.0 of 4-[1-(1-imidazolyl)-butyl]-benzoic acid, hydrochloride (of example 2) is dissolved in 30 ml of methanol, hydrochloric-acid gas is introduced for 10 minutes, refluxed for 30 minutes and concentrated by evaporation. The residue is distilled on a bulb tube, boiling point 190° C./0.03 mbar. 0.55 g of 4-[1-(1-imidazolyl)-butyl]-benzoic acid methyl ester is obtained.

Workup

  1. temperaturerefluxed for 30 minutes
  2. concentrationconcentrated by evaporation
  3. distillationThe residue is distilled on a bulb tube

Sources & evidence

ORD record
ord-35e1812d34b64fc0ac158ac903270011
Source dataset
uspto-grants-1991_09
Patent number
US05045558

Reaction notes

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