反应详情

温度

70 °C

50 g (0.43 mole) of 5-bromovanillin in 130 ml of DMF was added 150 g (1.08 mole) of potassium carbonate and 55 ml (0.606 mole) of bromopropane. The mixture was stirred for 72 hours at 70° C. The solution was then poured into 1 liter ice water. The aqueous solution was extracted with 3×200 ml CH2Cl2, the combined organic extracts were dried over MgSO4. The solution was filtered and the filtrate was concentrated to dryness to yield 66.80 g of 3-bromo-5-methoxy-4-propoxybenzaldehyde as a yellow oil. (95% yield).

1. extractionThe aqueous solution was extracted with 3×200 ml CH2Cl2
2. dry with materialthe combined organic extracts were dried over MgSO4
3. filtrationThe solution was filtered
4. concentrationthe filtrate was concentrated to dryness