Hydrochloric Acid → HCID 10594810, compound

HRID 728072Notes

Reaction equation

HRID 728072 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:12]=[CH:11][C:10]=1[CH2:23][CH2:24][C:25]([O:27]CC)=[O:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].Cl>C(O)C>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:12]=[CH:11][C:10]=1[CH2:23][CH2:24][C:25]([OH:27])=[O:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 11794744HCID 11794744, compound

Product 1

HCID 10594810HCID 10594810, compoundYield 84.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethyl 3-(2,4-dibenzyloxyphenyl)propionate (12.0 g) in ethanol (300 ml), sodium hydroxide (10.3 g) was added, followed by stirring at room temperature for 6 hours. The reaction mixture was adjusted to pH 4.0 with addition of 5N hydrochloric acid solution. Ethanol was distilled off and to the residue was added water. The precipitated crystal was collected by filtration, washed with water and dried to obtain as colorless crystal 3-(2,4-dibenzyloxyphenyl)propionic acid (9.4 g).

Workup

  1. distillationEthanol was distilled off and to the residue
  2. additionwas added water
  3. filtrationThe precipitated crystal was collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-11483137b69d45fd8cfc27a5199ba21a
Source dataset
uspto-grants-1991_09
Patent number
US05047430

Reaction notes

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