Ethyl isocyanate → HCID 15171530, compound

HRID 728141Notes

Reaction equation

HRID 728141 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]1[CH:17]=[CH:16][C:11]2[N:12]=[C:13]([NH2:15])[S:14][C:10]=2[CH:9]=1.[CH2:18]([N:20]=[C:21]=[O:22])[CH3:19]>O1CCCC1>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]1[CH:17]=[CH:16][C:11]2[N:12]=[C:13]([NH:15][C:21]([NH:20][CH2:18][CH3:19])=[O:22])[S:14][C:10]=2[CH:9]=1

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 10083053HCID 10083053, compound

Product 1

HCID 15171530HCID 15171530, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 6-[(2-pyridyl)methyl]-2-aminobenzothiazole (1.3 g) and ethyl isocyanate (0.6 ml) in tetrahydrofuran (25 ml) was stirred at 60° C. for 4 hours. Evaporation of the solvent gave a residue which was crystallized from tetrahydrofuran. The crystal was collected by filtration to give 6-[(2-pyridyl)methyl]-2-(3-ethylureido)benzothiazole (0.68 g).

Workup

  1. customEvaporation of the solvent
  2. customgave a residue which
  3. customwas crystallized from tetrahydrofuran
  4. filtrationThe crystal was collected by filtration

Sources & evidence

ORD record
ord-7fb4448cff0c49b6a34850e241827bf0
Source dataset
uspto-grants-1991_09
Patent number
US05047411

Reaction notes

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