Triphenylphosphine → HCID 19823306, compound

HRID 728187Notes

Reaction equation

HRID 728187 reaction equation
[Br:1][CH2:2][C:3]1[CH:16]=[CH:15][C:6]2[N:7]=[C:8]([N:10]([CH2:13][CH3:14])[CH:11]=[O:12])[O:9][C:5]=2[CH:4]=1.[C:17]1([P:23]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>O1CCCC1>[Br-:1].[CH2:13]([N:10]([C:8]1[O:9][C:5]2[CH:4]=[C:3]([CH2:2][P+:23]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:16]=[CH:15][C:6]=2[N:7]=1)[CH:11]=[O:12])[CH3:14]

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 15644570HCID 15644570, compound

Product 1

HCID 19823306HCID 19823306, compoundYield 76.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The mixture of 6-bromomethyl-2-(N-ethylformamido)benzoxazole (0.35 g) and triphenylphosphine (0.32 g) in tetrahydrofuran (5 ml) was refluxed for 1.8 hours and the mixture was cooled to 0°-5° C. The isolated precipitate was collected by filtration to give [2-(N-ethylformamido)benzoxazol-6-yl]methyltriphenylphosphonium bromide (0.51 g).

Workup

  1. temperaturewas refluxed for 1.8 hours
  2. temperaturethe mixture was cooled to 0°-5° C
  3. filtrationThe isolated precipitate was collected by filtration

Sources & evidence

ORD record
ord-6d753f778f9644fda4697d4b1f90a16f
Source dataset
uspto-grants-1991_09
Patent number
US05047411

Reaction notes

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