Trifluoroacetic acid → HCID 178436741, compound

HRID 72819Notes

Reaction equation

HRID 72819 reaction equation
[I-].C([N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:16]=[C:17]([CH2:36][CH3:37])[C:18]3[C:27]([CH:28]=2)=[S+:26][C:25]2[C:20](=[C:21]([CH3:35])[CH:22]=[C:23]([N:29]4[CH2:34][CH2:33][O:32][CH2:31][CH2:30]4)[CH:24]=2)[N:19]=3)[CH2:11][CH2:10]1)(OC(C)(C)C)=O.[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41]>ClCCl>[F:38][C:39]([F:44])([F:43])[C:40]([O-:42])=[O:41].[CH2:36]([C:17]1[C:18]2[C:27](=[S+:26][C:25]3[C:20]([N:19]=2)=[C:21]([CH3:35])[CH:22]=[C:23]([N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)[CH:24]=3)[CH:28]=[C:15]([N:12]2[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]2)[CH:16]=1)[CH3:37]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178436742HCID 178436742, compound

Product 1

HCID 178436741HCID 178436741, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 3-(4-Boc-piperazin-1-yl)-1-ethyl-9-methyl-7-morpholinophenothiazin-5-ium iodide (65 mg, 0.01 mmol) in dichloromethane (10 mL) and trifluoroacetic acid (1.0 mL) was stirred for 1 h at 50° C. The resulting mixture was washed by toluene (2×5 mL), pentane (2×5 mL) and concentrated to dryness.

Workup

  1. washThe resulting mixture was washed by toluene (2×5 mL), pentane (2×5 mL)
  2. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-df671367bca54720b6beb02e1c0edada
Source dataset
uspto-grants-2014_09
Patent number
US08828986B2

Reaction notes

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