Dichloromethane → HCID 178436735, compound

HRID 72822Notes

Reaction equation

HRID 72822 reaction equation
[I-].[CH2:2]([C:4]1[C:17]2[C:8](=[S+:9][C:10]3[C:15]([N:16]=2)=[C:14]([CH3:18])[CH:13]=[C:12]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[CH:11]=3)[CH:7]=[C:6]([N:25]2[CH2:31][CH2:30][CH2:29][N:28](C(OC(C)(C)C)=O)[CH2:27][CH2:26]2)[CH:5]=1)[CH3:3].[Cl:39]CCl>Cl>[Cl-:39].[CH2:2]([C:4]1[C:17]2[C:8](=[S+:9][C:10]3[C:15]([N:16]=2)=[C:14]([CH3:18])[CH:13]=[C:12]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[CH:11]=3)[CH:7]=[C:6]([N:25]2[CH2:31][CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH:5]=1)[CH3:3]

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 178436739HCID 178436739, compound

Product 1

HCID 178436735HCID 178436735, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 1-ethyl-9-methyl-7-morpholino-3-(4-Boc-1,4-diazepane-1-yl)phenothiazin-5-ium iodide (65 mg, 0.1 mmol) in dichloromethane (10 mL) and HCl (1.0 mL, 4 M solution in 1,4-dioxane) was stirred for 2 h at 50° C. Product was precipitated, liquid was decanted. Solid material was dissolved in methanol and concentrated to dryness.

Workup

  1. customProduct was precipitated
  2. customliquid was decanted
  3. dissolutionSolid material was dissolved in methanol
  4. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-e86c8bb1a9114fd6ae5166302d0baa88
Source dataset
uspto-grants-2014_09
Patent number
US08828986B2

Reaction notes

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