Acetic Acid → HCID 54143333, compound

HRID 728303Notes

Reaction equation

HRID 728303 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:12](=O)[CH3:13])[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:15][N:16]([CH3:18])[NH2:17].C(O)(=O)C>C(O)C>[CH3:15][N:16]([CH3:18])[N:17]=[C:12]([C:8]1([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[CH2:11][CH2:10][CH2:9]1)[CH3:13]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 59761,1-DimethylhydrazineHCID 212584081-[1-(4-Chlorophenyl)cyclobutyl]ethanone

Product 1

HCID 54143333HCID 54143333, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1-[1-(4-chlorophenyl)cyclobutyl]-ethanone (40 g), N,N-dimethylhydrazine (50 ml), glacial acetic acid (2 ml) and ethanol (35 ml) was heated under reflux for 78 hours. Removal of the solvent gave a residue which was distilled (104°-106°/0.1 mm Hg) to give 1-[1-(4-chlorophenyl)cyclobutyl]ethanone N,N-dimethylhydrazone.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 78 hours
  3. customRemoval of the solvent
  4. customgave a residue which
  5. distillationwas distilled (104°-106°/0.1 mm Hg)

Sources & evidence

ORD record
ord-2570d4cf24f7454ab91ce74567d8807e
Source dataset
uspto-grants-1991_09
Patent number
US05047432

Reaction notes

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