Diethyl Sulfate → HCID 15028916, compound

HRID 728342Notes

Reaction equation

HRID 728342 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[N:13]1[C:17]([OH:18])=[C:16]([S:19][C:20]([F:23])([F:22])[F:21])[C:15]([C:24]([O:26][CH3:27])=[O:25])=[N:14]1.S(OCC)(O[CH2:32][CH3:33])(=O)=O.[H-].[Na+]>O1CCOCC1>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[N:13]1[C:17]([O:18][CH2:32][CH3:33])=[C:16]([S:19][C:20]([F:21])([F:22])[F:23])[C:15]([C:24]([O:26][CH3:27])=[O:25])=[N:14]1

Participants

5

Reactant 3

HCID 6163Diethyl SulfateHCID 24758Sodium hydrideHCID 178499159HCID 178499159, compound

Product 1

HCID 15028916HCID 15028916, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The intermediate was prepared according to process SCHEME I of EXAMPLE 1c by reacting 1-(2,6-dichloro-4-trifluoromethylphenyl)-3-methoxycarbonyl-4-trifluoromethylsulfenyl-5-hydroxypyrazole with diethyl sulfate and sodium hydride in dioxane. The following spectral data were obtained: MS, m/e=482(M+); NMR (CDCl3) δ1.43 (t, J=7.0 Hz, C2H5), 3.73 (s, OCH3), 4.4 (q, J=7.0, OCH2), and 7.76 (s, 2H aromatic).

Workup

  1. customThe intermediate was prepared
  2. customThe following spectral data were obtained

Sources & evidence

ORD record
ord-c952d5c63d5f4f3183b372b093031955
Source dataset
uspto-grants-1991_09
Patent number
US05047550

Reaction notes

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