Ethanol → HCID 54543603, compound

HRID 728547Notes

Reaction equation

HRID 728547 reaction equation
[C:1]([C:4]1[S:8][C:7]([CH3:9])=[N:6][C:5]=1[CH3:10])(=O)[CH3:2].[C:11]([NH:19][NH2:20])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(O)C>O>[CH3:9][C:7]1[S:8][C:4]([C:1](=[N:20][NH:19][C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH3:2])=[C:5]([CH3:10])[N:6]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 11955BenzoylhydrazineHCID 5208882,4-Dimethyl-5-acetylthiazole

Product 1

HCID 54543603HCID 54543603, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 5.0 gm (0.322 mole) of 5-acetyl-2,4-dimethylthiazole, 4.38 gm (0 0322 mole) of benzhydrazide, 10 drops of glacial acid and 100 ml of ethanol is refluxed 48 hrs. The reaction mixture is diluted with water to the cloud point then chilled. The product is collected and dried to give 4.75 gm (54%) of the title compound having a melting point of 138.4° C.

Workup

  1. temperatureis refluxed 48 hrs
  2. temperaturethen chilled
  3. customThe product is collected
  4. customdried

Sources & evidence

ORD record
ord-789d7cef10b748cabac080fbbade07d0
Source dataset
uspto-grants-1991_09
Patent number
US05049561

Reaction notes

Loading…