反应详情

To a RB flask equipped with magnetic stirring bar, reflux condenser, N2 inlet line with bubbler was aded acenaphtho[1,2-b]quinoline-10-methanol (14A, 2.25 g, 8 mmol), barium manganate (Aldrich, 4.0 g, 16 mmol) and dry CH2Cl2 (1 L). The mixture was refluxed for 24 h, filtered and the resulting dark yellow solution filtered and the solvent removed by rotary evaporation to give a dark green solid. This material was dissolved in a mixture of EtOAc (700 mL) and THF (200 mL) and passed through a small plug of SiO2 using EtOAc as the eluting solvent. The appropriate fractions were combined and the solvent removed by rotary evaporation to give a 71.7% yield of acenaphtho[1,2-b]quinoline-10-carbaldehyde, mp 245°-246°, (C,H,N).

1. customTo a RB flask equipped with magnetic stirring bar
2. temperaturereflux condenser, N2 inlet line with bubbler
3. temperatureThe mixture was refluxed for 24 h
4. filtrationfiltered
5. filtrationthe resulting dark yellow solution filtered
6. customthe solvent removed by rotary evaporation
7. customto give a dark green solid
8. customthe solvent removed by rotary evaporation