Triethylamine → 4-(3-Methoxyphenyl)-1-(phenylmethyl)-2-piperazinecarboxamide

HRID 728916Notes

Reaction equation

HRID 728916 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:9][CH2:10][CH2:11][NH:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:6]=[CH:7][CH:8]=1.Br[CH:21]([CH2:25]Br)[C:22]([NH2:24])=[O:23].C(N(CC)CC)C>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[CH2:10][CH2:11][N:12]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:21]([C:22]([NH2:24])=[O:23])[CH2:25]2)[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 857982,3-DibromopropionamideHCID 14998753N-(3-methoxyphenyl)-N'-(phenylmethyl)-1,2-ethanediamine

Product 1

HCID 149987544-(3-Methoxyphenyl)-1-(phenylmethyl)-2-piperazinecarboxamide

Procedure

In a manner similar to Preparation 1, react N-(3-methoxyphenyl)-N'-(phenylmethyl)-1,2-ethanediamine (16 g, 63 mmol) with 2,3-dibromopropanamide (29 g, 126 mmol) and triethylamine (25 g, 0.25mol) to give the title compound.

Workup

  1. customIn a manner similar to Preparation 1

Sources & evidence

ORD record
ord-aab76a66a86f430f84704cda31947069
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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