反应详情

温度

85 °C

Combine N-(3-aminophenyl)acetamide (31 g, 0.206 mol) and N-(2-chloroethyl)benzenemethanamine hydrochloride (17.0 g, 0.083 mol) and heat to 180° C. for 1 h. After this time, allow to cool to approximately 85° C. and add isopropanol (100 mL) to precipitate a solid. Decant the solvent and dissolve the white residue in refluxing methanol (800 mL). Filter hot and allow the solution to cool to room temperature. After 2 h, filter the resulting white solid and wash with methanol (50 mL) to give the title compound.

1. customto precipitate a solid
2. customDecant the solvent
3. dissolutiondissolve the white residue
4. temperaturein refluxing methanol (800 mL)
5. filtrationFilter hot
6. temperatureto cool to room temperature
7. filtrationfilter the resulting white solid
8. washwash with methanol (50 mL)