4-Nitrobenzyl chloride → HCID 14998826, compound

HRID 728946Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([O:24][CH3:25])[CH:17]=3)[CH:11]([CH2:26][OH:27])[CH2:10]2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.[H-].[Na+].Cl[CH2:31][C:32]1[CH:37]=[CH:36][C:35]([N+:38]([O-:40])=[O:39])=[CH:34][CH:33]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([O:24][CH3:25])[CH:17]=3)[CH:11]([CH2:26][O:27][CH2:31][C:32]3[CH:37]=[CH:36][C:35]([N+:38]([O-:40])=[O:39])=[CH:34][CH:33]=3)[CH2:10]2)[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

Reactant 3

HCID 74824-Nitrobenzyl chloride

HCID 24758Sodium hydride

HCID 14998825HCID 14998825, compound

Product 1

HCID 14998826HCID 14998826, compound

Procedure

In a manner similar to Preparation 19, react 4-(3,5-dichlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-2-piperazinemethanol with sodium hydride and 1-(chloromethyl)-4-nitrobenzene to give the titlecompound.

Workup

customIn a manner similar to Preparation 19
customto give the titlecompound

Sources & evidence

ORD record: ord-fe9bb048814e47c8b5bddcbc99db96c1
Source dataset: uspto-grants-1991_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05051422

Reaction notes

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