N-[[4-(2-Methoxyphenyl)-1-(phenylmethyl)piperazin-2-yl]methyl]4-[(methylsulfonyl)amino]benzamide hydrochloride → N-[[4-(2-Methoxyphenyl)piperazin-2-yl]methyl]-4-[(methylsulfonyl)amino]benzamide hydrochloride

HRID 728981Notes

Reaction equation

HRID 728981 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH2:15][CH2:14][N:13](CC2C=CC=CC=2)[CH:12]([CH2:23][NH:24][C:25](=[O:37])[C:26]2[CH:31]=[CH:30][C:29]([NH:32][S:33]([CH3:36])(=[O:35])=[O:34])=[CH:28][CH:27]=2)[CH2:11]1>[OH-].[OH-].[Pd+2]>[ClH:1].[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH2:15][CH2:14][NH:13][CH:12]([CH2:23][NH:24][C:25](=[O:37])[C:26]2[CH:31]=[CH:30][C:29]([NH:32][S:33]([CH3:36])(=[O:35])=[O:34])=[CH:28][CH:27]=2)[CH2:11]1

Participants

3

Reactant 1

HCID 19755013N-[[4-(2-Methoxyphenyl)-1-(phenylmethyl)piperazin-2-yl]methyl]4-[(methylsulfonyl)amino]benzamide hydrochloride

Product 1

HCID 67902867N-[[4-(2-Methoxyphenyl)piperazin-2-yl]methyl]-4-[(methylsulfonyl)amino]benzamide hydrochloride

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

In a manner similar to Example 1, react N-[[4-(2-methoxyphenyl)-1-(phenylmethyl)piperazin-2-yl]methyl]-4-[(methylsulfonyl)amino]benzamide hydrochloride (8.7 g, 16 mmol) with H2 over Pd(OH)2 (0.2 g) catalyst to give the title compound.

Sources & evidence

ORD record
ord-875576f4b0cd4b80b36aea1b811ab3ac
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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