Sulfuric Acid → N-[[4-(3-Chlorophenyl)piperazin-2-yl]methyl]-N-(1-methylethyl)-4-[(methylsulfonyl)amino]benzamide

HRID 728984Notes

Reaction equation

HRID 728984 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11](CC3C=CC(OC)=C(OC)C=3)[CH:10]([CH2:25][N:26]([CH:40]([CH3:42])[CH3:41])[C:27](=[O:39])[C:28]3[CH:33]=[CH:32][C:31]([NH:34][S:35]([CH3:38])(=[O:37])=[O:36])=[CH:30][CH:29]=3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.OS(O)(=O)=O>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][NH:11][CH:10]([CH2:25][N:26]([CH:40]([CH3:42])[CH3:41])[C:27](=[O:39])[C:28]3[CH:33]=[CH:32][C:31]([NH:34][S:35]([CH3:38])(=[O:37])=[O:36])=[CH:30][CH:29]=3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 19755015HCID 19755015, compound

Product 1

HCID 14998862N-[[4-(3-Chlorophenyl)piperazin-2-yl]methyl]-N-(1-methylethyl)-4-[(methylsulfonyl)amino]benzamide

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

In a manner similar to Example 11, react N-[[4-(3-chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]piperazin-2-yl]methyl]-N-(1-methylethyl)-4-[(methylsulfonyl)amino]benzamide with methoxybenzeneand a 5% solution of concentrated H2SO4 in trifluoroacetic acid to obtain the title compound.

Sources & evidence

ORD record
ord-82ae2b940737441a85eb2c14358ced5b
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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