Hydrochloric Acid → HCID 54523481, compound

HRID 729017Notes

Reaction equation

HRID 729017 reaction equation
Cl.[NH2:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])=[O:6].[O:13]1[CH2:25][CH:14]1[CH2:15][O:16][C:17]1[CH:24]=[CH:23][CH:22]=[CH:21][C:18]=1[C:19]#[N:20].[OH-].[Na+].C(C1C=CC=CC=1OCC(O)CNCCC(OCCCC)=O)#N>CCOCC>[C:19]([C:18]1[CH:21]=[CH:22][CH:23]=[CH:24][C:17]=1[O:16][CH2:15][CH:14]([OH:13])[CH2:25][NH:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])=[O:6])#[N:20]

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 126196712-(Oxiran-2-ylmethoxy)benzonitrileHCID 53791003HCID 53791003, compoundHCID 54460088HCID 54460088, compound

Product 1

HCID 54523481HCID 54523481, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

This compound was prepared in accordance with Example 1 using 6.9 g of the hydrochloride of pentyl 3-aminopropanoate, 5.5 g of 2-(2,3-epoxypropoxy)benzonitrile and 1.8 g of NaOH. The crude oil was treated with ether and butyl N-[3-(2-cyanophenoxy)-2-hydroxypropyl]-3-aminopropanoate crystallized. Yield 1.3 g. Melting point 91° C. (HCl). The structure was determined using NMR and equivalent weight.

Workup

  1. customcrystallized

Sources & evidence

ORD record
ord-8665bdd9e3ff47c79640c8e82efe0a42
Source dataset
uspto-grants-1991_09
Patent number
US05051446

Reaction notes

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