Ammonium Hydroxide → HCID 14800670, compound

HRID 729022Notes

Reaction equation

HRID 729022 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:28]=[CH:27][C:16]([CH2:17][C:18]2[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=2)[C:21](Cl)=[O:22])=[CH:15][CH:14]=1.[OH-].[NH4+:30]>O1CCCC1>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:28]=[CH:27][C:16]([CH2:17][C:18]2[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=2)[C:21]([NH2:30])=[O:22])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 14800669HCID 14800669, compound

Product 1

HCID 14800670HCID 14800670, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-(4-(2-Quinolinylmethyloxy)benzyl)benzoyl chloride (0.05 mol) in tetrahydrofuran (300 ml) is treated with concentrated ammonium hydroxide (25 ml). The reaction mixture is stirred overnight at room temperature andthen evaporated and partitioned between ethyl acetate and water. The ethyl acetate fraction is dried and evaporated to give 3-(4-(2-quinolinylmethyloxy)benzyl)benzamide.

Workup

  1. customandthen evaporated
  2. custompartitioned between ethyl acetate and water
  3. dry with materialThe ethyl acetate fraction is dried
  4. customevaporated

Sources & evidence

ORD record
ord-a18c0c7c2a6b43bb813fc9dafa09627f
Source dataset
uspto-grants-1991_09
Patent number
US05051427

Reaction notes

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