Sodium Hydroxide → HCID 178420092, compound

HRID 729024Notes

Reaction equation

HRID 729024 reaction equation
[N-:1]=[N+:2]=[N-:3].[Na+].[Cl-].[NH4+].[N:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[CH:9][C:8]=1[CH2:17][O:18][C:19]1[CH:33]=[CH:32][C:22]([CH2:23][C:24]2[CH:25]=[C:26]([CH:29]=[CH:30][CH:31]=2)[C:27]#[N:28])=[CH:21][CH:20]=1.[OH-].[Na+]>CN(C)C=O>[N:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[CH:9][C:8]=1[CH2:17][O:18][C:19]1[CH:33]=[CH:32][C:22]([CH2:23][C:24]2[CH:25]=[C:26]([C:27]3[NH:28][N:3]=[N:2][N:1]=3)[CH:29]=[CH:30][CH:31]=2)=[CH:21][CH:20]=1

Participants

6

Reactant 4

HCID 14798Sodium HydroxideHCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 14800671HCID 14800671, compound

Product 1

HCID 178420092HCID 178420092, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of sodium azide (0.03 mol), ammonium chloride (0.03 mol) and 3-(4-(2-quinolinylmethyloxy)benzyl)benzonitrile (0.01 mol) in dimethylformamide (20 ml) are heated at 100° C. for 18 hours. The reaction is poured into aqueous 10% sodium hydroxide solution and washed with ethyl acetate. The crystalline product is isolated by acidification and filtration to obtain 5-(3-(4-(2-quinolinylmethyloxy)benzyl)phenyl)tetrazole.

Workup

  1. washwashed with ethyl acetate
  2. customThe crystalline product is isolated by acidification and filtration

Sources & evidence

ORD record
ord-1a5e027924b64ee89e7d2967de930663
Source dataset
uspto-grants-1991_09
Patent number
US05051427

Reaction notes

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