Methylamine → HCID 15749830, compound

HRID 729095Notes

Reaction equation

HRID 729095 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([CH3:21])[C:14]=3[N:13]=[C:12](Cl)[C:11]=2[CH:10]=[CH:9]1.[CH3:23][NH2:24]>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([CH3:21])[C:14]=3[N:13]=[C:12]([NH:24][CH3:23])[C:11]=2[CH:10]=[CH:9]1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 157498291-(2-Methylphenyl)-4-chloro-6-methylpyrrolo[3,2-c]quinoline

Product 1

HCID 15749830HCID 15749830, compound

Procedure

1-(2-Methylphenyl)-4-chloro-6-methylpyrrolo[3,2-c]quinoline (1.5 g, 4.9 mmol) and methylamine (33% in ethanol, 50 ml) were heated to 150° C. in a pressure vessel for 16 hours, then the solvent evaporated. Chromatography (silica gel, 2% methanolic ammonia in dichloromethane) and recrystallisation from aqueous ethanol yielded 1-(2-methylphenyl)-4-methylamino-6-methylpyrrolo[3,2-c]quinoline (0.62 g),m.p. 129°-130°.

Workup

  1. customthe solvent evaporated
  2. customChromatography (silica gel, 2% methanolic ammonia in dichloromethane) and recrystallisation from aqueous ethanol

Sources & evidence

ORD record
ord-d80577440c44419fa01be13b384caa64
Source dataset
uspto-grants-1991_09
Patent number
US05051508

Reaction notes

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