反应详情

The yielded phytandiol derivative (0.48 g) was dissolved in 25 ml of dimethyl formamide and 0.06 g (1.00 mmol) of sodium azide (Sigma-Aldrich) was added, followed by reflux for 5 hr in order to substitute azide for para-toluene sulfonyl group. The reaction mixture was extracted with 50 ml of methylene chloride solution and washed with saline. Following drying over anhydrous magnesium sulfate, filtration and concentration, 0.29 g of azido phytandiol derivative was yielded.

1. temperatureby reflux for 5 hr in order
2. extractionThe reaction mixture was extracted with 50 ml of methylene chloride solution
3. washwashed with saline
4. dry with materialFollowing drying over anhydrous magnesium sulfate, filtration and concentration