Benzenamine, 4-(4-morpholinyl)- → HCID 11590352, compound

HRID 729326Notes

Reaction equation

HRID 729326 reaction equation
Cl[C:2]1[C:3](=[O:19])[N:4]([CH2:15][CH2:16][O:17][CH3:18])[S:5](=[O:14])(=[O:13])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[N:20]1([C:26]2[CH:32]=[CH:31][C:29]([NH2:30])=[CH:28][CH:27]=2)[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>>[CH3:18][O:17][CH2:16][CH2:15][N:4]1[C:3](=[O:19])[C:2]([NH:30][C:29]2[CH:28]=[CH:27][C:26]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[CH:32][CH:31]=2)=[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[S:5]1(=[O:14])=[O:13]

Participants

3

Reactant 2

HCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 672439094-Chloro-2-(2-methoxyethyl)-5-phenylisothiazol-3(2H)-one 1,1-dioxide

Product 1

HCID 11590352HCID 11590352, compound

Procedure

The title compound was prepared from 4-chloro-2-(2-methoxyethyl)-5-phenylisothiazol-3(2H)-one 1,1-dioxide and 4-morpholin-4-ylaniline in a similar manner as described for Examples 9 and 13. 1H NMR (400 MHz, CD3CN): δ 2.92-2.97 (m, 4H), 3.38 (s, 3H), 3.70-3.75 (m, 6H), 3.90 (t, 2H), 6.51-6.56 (m, 2H), 6.68-6.72 (m, 2H), 7.08-7.16 (m, 4H), 7.22-7.27 (m, 1H), 7.67 (bs, 1H); Mass Spectrum: M+H+ 444.

Sources & evidence

ORD record
ord-dae9fa8e60444869bfe3741b60aef5e3
Source dataset
uspto-grants-2009_09
Patent number
US07582629B2

Reaction notes

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