反应详情

温度

120 °C

To a solution of 100 mg (0.31 mmol) of (2E)-3-(dimethylamino)-1-[2-(4-methoxyphenyl)pyrazolo[1,5-b]pyridazin-3-yl]prop-2-en-1-one in 5 ml of N,N-dimethylformamide were added 103 mg (0.39 mmol) of N-phenylguanidinium nitrate and 153 mg (1.11 mmol) of potassium carbonate. The mixture was stirred at 120° C. for 28 hours. Removal of solvent followed by column chromatography with dichloromethane:methanol=100:1 gave the crude product. The crude product was washed with dichloromethane to afford the desired compound in 30% yield.

1. customRemoval of solvent
2. custommethanol=100:1 gave the crude product
3. washThe crude product was washed with dichloromethane