反应详情

温度

90 °C

A mixture of 5-bromo-2-chloropyrimidine (5 g, 25.8 mmol), piperidin-4-ol (2.88 g, 28.4 mmol) and triethylamine (5.40 mL, 38.8 mmol) in EtOH (51.7 mL) was heated at 90° C. for 0.5 h. The solvent was evaporated, the residue was diluted with 1N HCl (20 mL) and extracted with EtOAc (3×15 mL). The combined organic fractions were dried over Na2SO4 and the solvent was evaporated. The product was recrystallized from CH2Cl2/hexanes, filtered and washed with hexanes to afford the title product.

1. customThe solvent was evaporated
2. additionthe residue was diluted with 1N HCl (20 mL)
3. extractionextracted with EtOAc (3×15 mL)
4. dry with materialThe combined organic fractions were dried over Na2SO4
5. customthe solvent was evaporated
6. customThe product was recrystallized from CH2Cl2/hexanes
7. filtrationfiltered
8. washwashed with hexanes