Methanesulfonic Acid → HCID 86760942, compound

HRID 729624Notes

Reaction equation

HRID 729624 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([NH:17][C:18]([NH:20][C:21]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[C:24]([N:31]3[CH2:36][CH2:35][N:34]([C:37](=[O:42])[C:38]([CH3:41])([CH3:40])[CH3:39])[CH2:33][CH2:32]3)=[N:23][CH:22]=2)=[O:19])[N:8]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=2)[N:9]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:43][S:44]([OH:47])(=[O:46])=[O:45]>ClCCl>[S:44]([OH:47])(=[O:46])(=[O:45])[CH3:43].[C:1]([C:5]1[CH:6]=[C:7]([NH:17][C:18]([NH:20][C:21]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[C:24]([N:31]3[CH2:36][CH2:35][N:34]([C:37](=[O:42])[C:38]([CH3:41])([CH3:40])[CH3:39])[CH2:33][CH2:32]3)=[N:23][CH:22]=2)=[O:19])[N:8]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=2)[N:9]=1)([CH3:3])([CH3:4])[CH3:2]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 690526291-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-{1-[4-(2,2-dimethyl-propionyl)-piperazin-1-yl]-isoquinolin-4-yl}-urea

Product 1

HCID 86760942HCID 86760942, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Stir 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-{1-[4-(2,2-dimethyl-propionyl)-piperazin-1-yl]-isoquinolin-4-yl}-urea at room temperature. Add 1N methanesulfonic acid solution in dichloromethane to form the title compound. LCMS ES+ (m/z) 568 [M+H].

Sources & evidence

ORD record
ord-96d17d6f9df3449bab1d0a4b1aee0362
Source dataset
uspto-grants-2009_09
Patent number
US07582638B2

Reaction notes

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