Water → HCID 66702018, compound

HRID 729645Notes

Reaction equation

HRID 729645 reaction equation
C([N:4]([CH2:8][CH3:9])[CH:5]([CH3:7])[CH3:6])(C)C.[CH2:10]([S:17][C:18]1[N:23]=[C:22]([NH2:24])C=C(Cl)[N:19]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[OH2:26]>CN1C(=O)CCC1>[NH2:24][C:22]1[N:23]=[C:18]([S:17][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:19]=[C:8]([NH:4][C@H:5]([CH3:6])[CH2:7][OH:26])[CH:9]=1

Participants

5

Reactant 3

HCID 962WaterHCID 81531DiisopropylethylamineHCID 1228304-Amino-2-(benzylthio)-6-chloropyrimidine

Product 1

HCID 66702018HCID 66702018, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

N,N-Diisopropylethylamine (6.0 ml) was added to a solution of R-alaninol (12.0 ml) and 2-(benzylthio)-6-chloropyrimidin-4-amine (1.9 g) (Nugent, R. A., et al. PCT Int. Appl. 1996. 252 pp. WO9635678-A1) in NMP (6 ml) and stirred at 100° C. for three days before pouring into H2O (200 ml) and filtration of the precipitate. This solid was dried in vacuo to afford the subtitle compound as a pale sandy yellow solid. Yield: 4.1 g.

Workup

  1. customThis solid was dried in vacuo

Sources & evidence

ORD record
ord-7e948e3acd864b7a9c0a15270f7704e0
Source dataset
uspto-grants-2009_09
Patent number
US07582644B2

Reaction notes

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