Piperidine → 1-Piperidinesulfonamide

HRID 729680Notes

Reaction equation

HRID 729680 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[S:7](N)([NH2:10])(=[O:9])=[O:8]>O1CCOCC1>[N:1]1([S:7]([NH2:10])(=[O:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 82267Sulfamide

Product 1

HCID 2767411-Piperidinesulfonamide

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Piperidine (3.0 g) and sulfamide (5.93 g) in 1,4-dioxane (100 ml) were heated at reflux for 24 h. The solvent was evaporated under reduced pressure and the resulting solid suspended in CHCl3. The suspension was filtered and the filtrate concentrated in vacuo to afford the subtitle compound as a white solid. Yield: 3.85 g.

Workup

  1. temperatureat reflux for 24 h
  2. customThe solvent was evaporated under reduced pressure
  3. filtrationThe suspension was filtered
  4. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-88e11c5302b646108ea2f0d671bdaa1d
Source dataset
uspto-grants-2009_09
Patent number
US07582644B2

Reaction notes

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