Methylamine hydrochloride → HCID 58860834, compound

HRID 729723Notes

Reaction equation

HRID 729723 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]([CH2:23][CH:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)[C:12]([NH:14][C:15]2[S:16][C:17]([C:20]([OH:22])=O)=[CH:18][N:19]=2)=[O:13])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH3:30][NH2:31].Cl>CCN(CC)CC>[CH3:30][NH:31][C:20]([C:17]1[S:16][C:15]([NH:14][C:12](=[O:13])[CH:11]([C:8]2[CH:9]=[CH:10][C:5]([S:2]([CH3:1])(=[O:3])=[O:4])=[CH:6][CH:7]=2)[CH2:23][CH:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)=[N:19][CH:18]=1)=[O:22]

Participants

4

Reactant 2

HCID 6364545Methylamine hydrochlorideHCID 21093936HCID 21093936, compound

Product 1

HCID 58860834HCID 58860834, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

2-[2-(4-Methanesulfonylphenyl)-3-(tetrahydropyran-4-yl)propionylamino]thiazole-5-carboxylic acid (EXAMPLE 127, 399 mg, 0.91 mmol) was condensed with MeNH2.HCl in the presence of NEt3, utilising the general procedure described in EXAMPLE 65, to give the title compound: RTA=2.82 min; m/z (ES+)=452.3 [M+H]+.

Sources & evidence

ORD record
ord-977d900e65a04a4aa18c652f7f5400e7
Source dataset
uspto-grants-2009_09
Patent number
US07582632B2

Reaction notes

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