4-Aminophenol → 4-(2-Chloro-pyridin-4-yloxy)-phenylamine

HRID 729899Notes

Reaction equation

HRID 729899 reaction equation
NC1C=C(C=CC=1)OC1C=CN=C(C(N)=O)C=1.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=1.[Cl:26][C:27]1[CH:32]=[C:31](Cl)[CH:30]=[CH:29][N:28]=1>>[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][C:31]2[CH:30]=[CH:29][N:28]=[C:27]([Cl:26])[CH:32]=2)=[CH:21][CH:20]=1

Participants

4

Reactant 3

HCID 4034-AminophenolHCID 335152,4-DichloropyridineHCID 231372294-(3-Aminophenoxy)pyridine-2-carboxamide

Product 1

HCID 578334304-(2-Chloro-pyridin-4-yloxy)-phenylamine

Procedure

4-(4-Aminophenoxy)-2-chloropyridine was prepared by a method analogous to that described for 4-(3-aminophenoxy) pyridine-2-carboxamide (2C), starting from 4-aminophenol and 2,4-dichloropyridine MS ES: 221 (M+H)+, calcd 221, RT=0.32 min.

Sources & evidence

ORD record
ord-447acc73c8ca4a25b81a623203e7a9d7
Source dataset
uspto-grants-2009_09
Patent number
US07582645B2

Reaction notes

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