Hydrochloric Acid → HCID 178446133, compound

HRID 730014Notes

Reaction equation

HRID 730014 reaction equation
[C:1]([C:5]1[NH:6][C:7]([C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)=[C:8]([C:10]2[N:15]=[C:14]3[N:16]([CH2:20][C:21]([CH3:24])([CH3:23])[CH3:22])[C:17]([NH2:19])=[N:18][C:13]3=[CH:12][CH:11]=2)[N:9]=1)([CH3:4])([CH3:3])[CH3:2].[ClH:32]>CC(C)=O>[ClH:32].[ClH:32].[C:1]([C:5]1[NH:6][C:7]([C:25]2[CH:26]=[CH:27][C:28]([F:31])=[CH:29][CH:30]=2)=[C:8]([C:10]2[N:15]=[C:14]3[N:16]([CH2:20][C:21]([CH3:24])([CH3:23])[CH3:22])[C:17]([NH2:19])=[N:18][C:13]3=[CH:12][CH:11]=2)[N:9]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178446132HCID 178446132, compound

Product 1

HCID 178446133HCID 178446133, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Dissolve 126 mg (0.3 mmol) 5-[2-tert-butyl-5-(4-fluoro-phenyl)-1H-imidazol-4-yl]-3-(2,2-dimethyl-propyl)-3H-imidazo[4,5-b]pyridin-2-ylamine in 2.0 mL acetone. Add 120 μL of 5N hydrochloric acid incrementally. Filter the resultant precipitate. Air dry to provide 140 mg (93%) of very light pink crystals.

Workup

  1. filtrationFilter the resultant precipitate
  2. customAir dry
  3. customto provide 140 mg (93%) of very light pink crystals

Sources & evidence

ORD record
ord-5e384e7750e94191b662c0925113c0cd
Source dataset
uspto-grants-2009_09
Patent number
US07582652B2

Reaction notes

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