Potassium Carbonate → HCID 15986635, compound

HRID 730084Notes

Reaction equation

HRID 730084 reaction equation
FC(F)(F)C([N:5]1[CH:10]2[CH2:11][CH2:12][CH:6]1[CH2:7][C:8](=[C:13]1[C:26]3[CH:25]=[CH:24][CH:23]=[C:22]([NH:27][CH:28]=[O:29])[C:21]=3[O:20][C:19]3[C:14]1=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:9]2)=O.C([O-])([O-])=O.[K+].[K+]>CO>[CH:10]12[NH:5][CH:6]([CH2:12][CH2:11]1)[CH2:7][C:8](=[C:13]1[C:26]3[CH:25]=[CH:24][CH:23]=[C:22]([NH:27][CH:28]=[O:29])[C:21]=3[O:20][C:19]3[C:14]1=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:9]2

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 57833600HCID 57833600, compound

Product 1

HCID 15986635HCID 15986635, compoundYield 48.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Compound 5k (0.42g, 0.98 mmol) was added to MeOH (10 mL), and K2CO3 (1 g) was added. The mixture was stirred for 3 h at rt. After that time, the solid was collected by vacuum filtration. The resulting filtrate was concentrated in vacuo. Water was added to the resulting residue and the mixture was stirred for 30 min. The solid was collected by vacuum filtration and purified by reverse phase HPLC to yield the title compound 44 (159 mg, 37%).

Workup

  1. additionwas added
  2. filtrationAfter that time, the solid was collected by vacuum filtration
  3. concentrationThe resulting filtrate was concentrated in vacuo
  4. additionWater was added to the resulting residue
  5. stirringthe mixture was stirred for 30 min
  6. filtrationThe solid was collected by vacuum filtration
  7. custompurified by reverse phase HPLC

Sources & evidence

ORD record
ord-b3d5105cb89f4473b26ba106fd4d2ddf
Source dataset
uspto-grants-2009_09
Patent number
US07582650B2

Reaction notes

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