Hydrochloric Acid → HCID 9882765, compound

HRID 730183Notes

Reaction equation

HRID 730183 reaction equation
Cl.[CH2:2]([NH:6][C:7]1[C:15]2[C:10](=[CH:11][C:12]([Cl:22])=[C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:14]=2)[N:9](COCC[Si](C)(C)C)[N:8]=1)[CH2:3][CH2:4][CH3:5]>CO>[CH2:2]([NH:6][C:7]1[C:15]2[C:10](=[CH:11][C:12]([Cl:22])=[C:13]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:14]=2)[NH:9][N:8]=1)[CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21079266HCID 21079266, compound

Product 1

HCID 9882765HCID 9882765, compoundYield 109.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.7 ml of 2N HCl is added to a solution of 21 mg of butyl[6-chloro-5-phenyl-1-(2-(trimethylsilanyl)ethoxymethyl)-1H-indazol-3-yl]amine in 0.3 cm3 of methanol. The reaction medium is stirred at ambient temperature for 48 hours and at reflux for 1 hour, then evaporated. The solid obtained is dried under vacuum to give 16 mg of N-butyl-6-chloro-5-phenyl-1H-indazol-3-amine (yellow solid).

Workup

  1. temperatureat reflux for 1 hour
  2. customevaporated
  3. customThe solid obtained
  4. customis dried under vacuum

Sources & evidence

ORD record
ord-fc4699b446724dc6999c140145307749
Source dataset
uspto-grants-2009_09
Patent number
US07582669B2

Reaction notes

Loading…