Indole → 3-Bromo-1h-indole

HRID 730552Notes

Reaction equation

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[Br:10]N1C(=O)CCC1=O>>[Br:10][C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][CH:2]=1

Participants

Reactant 2

HCID 798Indole

HCID 67184N-bromobutanimide

Product 1

HCID 27632773-Bromo-1h-indole

Procedure

In step 3 indole compound k undergoes bromination by treatment with N-bromosuccinimide or other bromime source (not shown) to yield 3-bromo indole compound l. Bromoindole l is then subject to oxidation in step 4 to provide dihydroindolone compound m. Compound m is a compound of formula I in accordance with the invention.

Sources & evidence

ORD record: ord-1537cf4be3484571bd51d70d51c62c2d
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07582760B2

Reaction notes

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