Diethyl Ether → HCID 68817750, compound

HRID 730572Notes

Reaction equation

HRID 730572 reaction equation
C(O[C:6](=O)[N:7]([CH2:9][CH2:10][C:11]1[C:19]2[NH:18][C:17](=[O:20])[N:16]([CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:15]=2[CH:14]=[CH:13][CH:12]=1)C)(C)(C)C.[ClH:29].CCO.C(OCC)C>O1CCCC1>[ClH:29].[CH2:21]([N:16]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:10][CH2:9][NH:7][CH3:6])[C:19]=2[NH:18][C:17]1=[O:20])[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 21887872Ethanol hydrochlorideHCID 57834991HCID 57834991, compound

Product 1

HCID 68817750HCID 68817750, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

[2-(1-Benzyl-2-oxo-2,3-dihydro-1H-benzoimidazol-4-yl)-ethyl]-methyl-carbamic acid tert-butyl ester (31 mg) was dissolved in 2.0 ml of tetrahydrofuran and 100 uL of 2.0 N HCl/EtOH was added. The solution was heated on a steam bath for 30 minutes and then after cooling diethyl ether was slowly added to produce 10 mg of 1-benzyl-4-(2-methylamino-ethyl)-1,3-dihydro-benzoimidazol-2-one hydrochloride salt as a colorless powder. MS: 282 (M+H)−.

Workup

  1. temperatureThe solution was heated on a steam bath for 30 minutes
  2. additionwas slowly added

Sources & evidence

ORD record
ord-4deadf5abd85402cb23a568c77f2bd90
Source dataset
uspto-grants-2009_09
Patent number
US07582760B2

Reaction notes

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