Lithium Hydroxide → HCID 135540802, compound

HRID 730663Notes

Reaction equation

HRID 730663 reaction equation
[Li+].[OH-].[O:3]=[C:4]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@H:18]([CH2:39][C:40]3[CH:45]=[C:44]([CH3:46])[C:43]([OH:47])=[C:42]([CH3:48])[CH:41]=3)[C:19]([N:21]3[CH2:26][CH2:25][CH:24]([CH:27]4[CH2:32][CH2:31][N:30]([CH2:33][C:34]([O:36]CC)=[O:35])[CH2:29][CH2:28]4)[CH2:23][CH2:22]3)=[O:20])=[O:16])[CH2:11][CH2:10]2)[N:7]=[C:6]([C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=2)[NH:5]1>O.C1COCC1>[O:3]=[C:4]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@H:18]([CH2:39][C:40]3[CH:41]=[C:42]([CH3:48])[C:43]([OH:47])=[C:44]([CH3:46])[CH:45]=3)[C:19]([N:21]3[CH2:26][CH2:25][CH:24]([CH:27]4[CH2:32][CH2:31][N:30]([CH2:33][C:34]([OH:36])=[O:35])[CH2:29][CH2:28]4)[CH2:23][CH2:22]3)=[O:20])=[O:16])[CH2:11][CH2:10]2)[N:7]=[C:6]([C:49]2[CH:50]=[CH:51][CH:52]=[CH:53][CH:54]=2)[NH:5]1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 135540801HCID 135540801, compound

Product 1

HCID 135540802HCID 135540802, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 1.2 mg (0.05 mmol) LiOH in 2 mL water was added to a solution of 21 mg (0.03 mmol) (R)-2-(1′-ethoxycarbonylmethyl-4,4′-bipiperidinyl-1-yl)-1-(4-hydroxy-3,5-dimethyl-benzyl)-2-oxo-ethyl 4-(5-oxo-3-phenyl-4,5-dihydro-1,2,4-triazol-1-yl)-piperidine-1-carboxylate in 3 mL THF and the reaction mixture was stirred for 1 h at RT. The THF was evaporated down i.vac., the residue was acidified with 1 M HCl and again evaporated down i.vac. The residue was purified by HPLC, the fractions containing the product were combined and lyophilised.

Workup

  1. customThe THF was evaporated down i.vac
  2. customagain evaporated down i.vac
  3. customThe residue was purified by HPLC
  4. additionthe fractions containing the product

Sources & evidence

ORD record
ord-0881f7af2c104a4cb0dd4c31996f1071
Source dataset
uspto-grants-2009_09
Patent number
US07582625B2

Reaction notes

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