2,3-Dichloropyridine → HCID 178461514, compound

HRID 730758Notes

Reaction equation

HRID 730758 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[Cl:9][C:10]1[C:15]2[NH:16][C:17]([N:19]3[CH2:24][CH2:23][NH:22][C@H:21]([CH3:25])[CH2:20]3)=[N:18][C:14]=2[CH:13]=[C:12]([C:26]([F:29])([F:28])[F:27])[CH:11]=1.C(N(CC)C(C)C)(C)C>>[Cl:9][C:10]1[C:15]2[NH:16][C:17]([N:19]3[CH2:24][CH2:23][N:22]([C:2]4[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][N:3]=4)[C@H:21]([CH3:25])[CH2:20]3)=[N:18][C:14]=2[CH:13]=[C:12]([C:26]([F:29])([F:28])[F:27])[CH:11]=1

Participants

4

Reactant 3

HCID 169882,3-DichloropyridineHCID 81531DiisopropylethylamineHCID 178461512HCID 178461512, compound

Product 1

HCID 178461514HCID 178461514, compound

Procedure

A mixture of 2,3-dichloro-pyridine (44 mg, 0.3 mmol, Aldrich), 7-chloro-2-[(3R)-3-methylpiperazin-1-yl]-5-(trifluoromethyl)-1H-benzoimidazole (80 mg, 0.25 mmol, Example 48a) and N,N-diisopropylethylamine (0.1 mL, 0.58 mmol, Aldrich) reacted under the conditions of Example 48b to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 430 (M+1).

Workup

  1. customreacted under the conditions of Example 48b

Sources & evidence

ORD record
ord-7d79c8bd2b5b43e48ed12fe63647c95e
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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