Piperazine → 2-Piperazin-1-yl-pyridine-3-sulfonic acid methylamide

HRID 730764Notes

Reaction equation

HRID 730764 reaction equation
Cl[C:2]1[C:7]([S:8]([NH:11][CH3:12])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1.C(N(CC)C(C)C)(C)C>>[CH3:12][NH:11][S:8]([C:7]1[C:2]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[N:3][CH:4]=[CH:5][CH:6]=1)(=[O:10])=[O:9]

Participants

4

Reactant 3

HCID 4837PiperazineHCID 81531DiisopropylethylamineHCID 32940542-chloro-N-methylpyridine-3-sulfonamide

Product 1

HCID 674013562-Piperazin-1-yl-pyridine-3-sulfonic acid methylamide

Procedure

A mixture of 2-chloro-N-methyl-3-pyridinesulfonamide (1 g, 4.8 mmol, Specs), piperazine (0.43 g, 5 mmol) and N,N-diisopropylethylamine (1 mL, 5.8 mmol, Aldrich) was reacted under the conditions of Example 41a to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 257 (M+1).

Workup

  1. customwas reacted under the conditions of Example 41a

Sources & evidence

ORD record
ord-f76cc9f6c9914ab18489db45e7df4c05
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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