Piperazine → (5-Chloro-6-(piperazin-1-yl)pyridin-3-yl)methanol

HRID 730770Notes

Reaction equation

HRID 730770 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][OH:10])[CH:5]=[N:6][C:7]=1Cl.[NH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.C(N(CC)C(C)C)(C)C>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][OH:10])[CH:5]=[N:6][C:7]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1

Participants

4

Reactant 3

HCID 4837PiperazineHCID 81531DiisopropylethylamineHCID 21882961(5,6-Dichloropyridin-3-yl)methanol

Product 1

HCID 11514124(5-Chloro-6-(piperazin-1-yl)pyridin-3-yl)methanol

Procedure

A mixture of 5,6-dichloro-3-pyridinemethanol (0.71 g, 4 mmol, TCI-US), piperazine (0.52 g, 6 mmol) and N,N-diisopropylethylamine (1 mL, 5.8 mmol, Aldrich) was reacted under the conditions of Example 43a to give the title compound as a light-yellow solid. MS (ESI, pos. ion) m/z: 228 (M+1).

Workup

  1. customwas reacted under the conditions of Example 43a

Sources & evidence

ORD record
ord-ab79dea75f3b4b9faa43f0cad17db1bd
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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