Triethylamine → HCID 178506241, compound

HRID 730825Notes

Reaction equation

HRID 730825 reaction equation
Cl[C:2]1[NH:3][C:4]2[C:5]([N:14]=1)=[N:6][CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=2.[F:15][C:16]([F:30])([F:29])[C:17]1[C:18]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[N:19][CH:20]=[CH:21][CH:22]=1.C(N(CC)CC)C>CC(C)CCO.[Cu]I>[F:11][C:10]([F:13])([F:12])[C:8]1[CH:9]=[C:4]2[N:3]=[C:2]([N:26]3[CH2:27][CH2:28][N:23]([C:18]4[C:17]([C:16]([F:30])([F:15])[F:29])=[CH:22][CH:21]=[CH:20][N:19]=4)[CH2:24][CH2:25]3)[NH:14][C:5]2=[N:6][CH:7]=1

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 27777861-[3-(Trifluoromethyl)pyridin-2-yl]piperazineHCID 116801682-Chloro-6-(trifluoromethyl)-3H-imidazo[4,5-B]pyridine

Product 1

HCID 178506241HCID 178506241, compound

Reagents, catalysts & solvents 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)CatalystHCID 31260Isoamyl AlcoholSolvent

Procedure

A mixture of 2-chloro-6-trifluoromethyl-1H-imidazo[4,5-b]pyridine from step (d) above (45 mg, 0.203 mmol), 1-(3-trifluoromethyl-pyridin-2-yl)-piperazine (47 mg, 0.203 mmol, Fluorochem), triethylamine (59 μL, 0.406 mmol, Aldrich) and copper(I) iodide (1 mg, 0.005 mmol, Aldrich) in 3-methyl-butan-1-ol (0.5 mL, Aldrich) was subjected to microwave irradiation at 220° C. for 0.5 h. The reaction mixture was cooled to room temperature and was filtered. The filtrate was purified by preparative HPLC (gradient 0.1% trifluoroacetic acid in acetonitrile) to give the title compound as a colorless solid. MS (ESI, positive ion) m/z: 417 (M+1).

Workup

  1. customirradiation at 220° C. for 0.5 h
  2. filtrationwas filtered
  3. customThe filtrate was purified by preparative HPLC (gradient 0.1% trifluoroacetic acid in acetonitrile)

Sources & evidence

ORD record
ord-c88bb84cd6a4453dbaae05f5b7b54d69
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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