反应详情

The desired product was prepared using a procedure similar to step 1 of example 4. Thus, 4-(1-benzyl-2,3-dimethyl-1H-indol-5-yl)-phenol (0.300 g, 0.916 mmol) was reacted with K2CO3 (0.152 g, 1.099 mmol) and methyl bromoacetate (0.168 g, 1.099 mmol) in acetone (10 ml) to give the product (0.233 g, 0.583 mmol, 64%) as a purple solid, mp 133-136° C. 1H NMR (DMSO-d6) δ 2.24 (s, 3H), 2.28 (s, 3H), 3.71 (s, 3H), 4.82 (s, 2H), 5.39 (s, 2H), 6.98 (d, J=8.6 Hz, 4H), 7.20 (t, J=7.2 Hz, 1H), 7.26-7.29 (m, 3H), 7.37 (d, J=8.4 Hz, 1H), 7.58 (d, J=8.7 Hz, 2H), 7.62 (s, 1H); [ESI(+)], m/z 400 (M+H)+.