反应详情

The desired product was prepared using a procedure similar to step 1 of example 4. Thus, 4-(3-benzyl-1,2-dimethyl-1H-indol-5-yl)-phenol (0.162 g, 0.495 mmol) was reacted with K2CO3 (0.089 g, 0.643 mmol) and methyl bromoacetate (0.098 g, 0.643 mmol) in acetone (5 ml) to give the product (0.161 g, 0.403 mmol, 81%) as an off-white solid, mp 113-117° C. 1H NMR (DMSO-d6) δ 2.40 (s, 3H), 3.67 (s, 3H), 3.70 (s, 3H), 4.06 (s, 2H), 4.80 (s, 2H), 6.96 (d, J=8.9 Hz, 2H), 7.08-7.11 (m, 1H), 7.19-7.24 (m, 4H), 7.29 (dd, J=1.7, 8.4 Hz, 1H), 7.39 (d, J=8.4 Hz, 1H), 7.51 (d, J=8.9 Hz, 2H), 7.56 (d, J=1.5 Hz, 1H); [ESI(+)], m/z 400 (M+H)+.