Ammonium Chloride → HCID 178421937, compound

HRID 731085Notes

Reaction equation

HRID 731085 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[C:6]([C:11]3[CH:20]=[CH:19][C:14]([O:15][CH2:16][C:17]#[N:18])=[CH:13][CH:12]=3)[CH:7]=[CH:8][CH:9]=2)[C:4]([CH3:21])=[C:3]1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[N-:28]=[N+:29]=[N-:30].[Na+].[NH4+].[Cl-]>CN(C=O)C>[CH3:1][N:2]1[C:10]2[C:5](=[C:6]([C:11]3[CH:20]=[CH:19][C:14]([O:15][CH2:16][C:17]4[NH:30][N:29]=[N:28][N:18]=4)=[CH:13][CH:12]=3)[CH:7]=[CH:8][CH:9]=2)[C:4]([CH3:21])=[C:3]1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 68813959HCID 68813959, compound

Product 1

HCID 178421937HCID 178421937, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The desired product was prepared using a procedure similar to step 6 of example 3. Thus, [4-(1,3-dimethyl-2-phenyl-1H-indol-4-yl)-phenoxy]-acetonitrile (0.311 g, 0.882 mmol) was reacted with NaN3 (0.287 g, 4.412 mmol) and NH4Cl (0.236 g, 4.412 mmol) in DMF (5 ml) to give the product (0.246 g, 0.622 mmol, 71%) as a white solid, dec. 208-210° C.

Sources & evidence

ORD record
ord-682c165fc6144341aee79a0e98eaf1d5
Source dataset
uspto-grants-2009_09
Patent number
US07582773B2

Reaction notes

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