Hydrochloric Acid → Trientine tetrahydrochloride

HRID 731132Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][NH:7][CH2:8][CH2:9][NH2:10].[ClH:11]>>[ClH:11].[ClH:11].[ClH:11].[ClH:11].[NH2:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][NH:7][CH2:8][CH2:9][NH2:10]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 5565Triethylenetetramine

Product 1

HCID 71434Trientine tetrahydrochlorideYield 90%

Procedure

Also provided are the formation of triethylenetetramine quaternary salts. In an additional embodiment, a tribenzaldehyde protected intermediate is reacted with at least more than about three equivalents of aqueous hydrochloric acid, for example, to form triethylenetetramine tetrahydrochloride, which is precipitated in greater than about 90% yield and greater than about 98% purity from isopropanol.

Workup

customAlso provided

Sources & evidence

ORD record: ord-777383455f0f45e9a9ea0a4464e89dc7
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07582796B2

Reaction notes

Loading…