Imidazole → HCID 66520354, compound

HRID 731406Notes

Reaction equation

HRID 731406 reaction equation
Br.[NH2:2][C:3]1[S:4][C:5](Br)=[CH:6][N:7]=1.C(=O)([O-])[O-].[K+].[K+].[NH:15]1[CH:19]=[CH:18][N:17]=[CH:16]1>CN(C=O)C>[N:15]1([C:5]2[S:4][C:3]([NH2:2])=[N:7][CH:6]=2)[CH:19]=[CH:18][N:17]=[CH:16]1

Participants

5

Reactant 3

HCID 795ImidazoleHCID 11430Potassium CarbonateHCID 27238485-Bromothiazol-2-amine monohydrobromide

Product 1

HCID 66520354HCID 66520354, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 2-amino-5-bromothiazole hydrobromide (0.5 g, 1.92 mmol), DMF (6 mL), potassium carbonate (1.0 g, 7.2 mmol), and imidazole (132 mg, 1.94 mmol) was stirred at room temperature for 6 h. The mixture was filtered and the filtrate evaporated to dryness in vacuo. The crude product was purified on a silica gel column (eluent: gradient from 100% methylene chloride to 100% isopropanol) to give 5-imidazol-1-yl-thiazol-2-ylamine. Yield: 0.16 g (50

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate evaporated to dryness in vacuo
  3. customThe crude product was purified on a silica gel column (eluent: gradient from 100% methylene chloride to 100% isopropanol)

Sources & evidence

ORD record
ord-e94a1d5f8be6459f965d2cdf7f37091e
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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