Hydrochloric Acid → HCID 178495639, compound

HRID 731425Notes

Reaction equation

HRID 731425 reaction equation
C([O:3][C:4](=[O:31])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([N:15]([CH:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)[C@H:16]2[CH2:21][CH2:20][C@H:19]([CH2:22][O:23][CH3:24])[CH2:18][CH2:17]2)=[O:14])=[N:9][CH:8]=1)C.[OH-].[Na+].Cl>CO>[CH:25]1([N:15]([C@H:16]2[CH2:17][CH2:18][C@H:19]([CH2:22][O:23][CH3:24])[CH2:20][CH2:21]2)[C:13](=[O:14])[NH:12][C:10]2[S:11][C:7]([S:6][CH2:5][C:4]([OH:31])=[O:3])=[CH:8][N:9]=2)[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178473156HCID 178473156, compound

Product 1

HCID 178495639HCID 178495639, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

{2-[3-Cyclohexyl-3-(trans-4-methoxymethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester was dissolved in methanol (10 mL) and 1N sodium hydroxide (5 mL) was added. Stirred at room temperature for 3 h then acidified with 1N hydrochloric acid. The white precipitate was filtered and dried to give the title compound (97 mg).

Workup

  1. filtrationThe white precipitate was filtered
  2. customdried

Sources & evidence

ORD record
ord-be3d61a7be60499ebaa96419435d4dde
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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